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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples. This article is published with open access at Springerlink. It is then legitimate to ask the question as to whether, despite the many kinds of agent involved, there may be at least some unifying mechanisms of such cell death and destruction. I summarise the evidence that in a great many cases, one underlying mechanism, providing major stresses of this type, entails continuing and autocatalytic production based on positive feedback mechanisms of hydroxyl radicals via Fenton chemistry involving poorly liganded iron, leading to cell death via apoptosis probably including via pathways induced by changes in the NF-kB system. While every pathway is in some sense connected to every other one, I highlight the literature evidence suggesting that the degenerative effects of many diseases and toxicological insults converge on iron dysregulation. This highlights specifically the role of iron metabolism, and the detailed speciation of iron, in chemical and other toxicology, and has significant implications for the use of iron chelating substances probably in partnership with appropriate anti-oxidants as nutritional or therapeutic agents in inhibiting both the progression of these mainly degenerative diseases and the sequelae of both chronic and acute toxin exposure. The complexity of biochemical networks, especially those involving autocatalytic behaviour and positive feedbacks,.

This volume of the Handbook of Neurochemistry and Molecular Neurobiology focuses on neurochemical aspects of schizophrenia. Chapters cover the full range of schizophrenia symptoms and anatomical pathologies from neurochemical and molecular biology perspectives. Topics include changes in neurotransmitter systems, alteration in receptors, neurotransmitter release, genetic factors, protein alterations, and redox dysregulation. Skip to main content Skip to table of contents. Advertisement Hide. Handbook of Neurochemistry and Molecular Neurobiology Schizophrenia.

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Organic Geochemistry, Climate of the Past, 15 2. Paleoceanography and Paleoclimatology. Earth and Planetary Science Letters, Geophysical Research Letters, Scientific Reports, 9 1.


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